Workshop reports, peer reviews, and committee reports are scanned for passages containing open questions, suggested research directions, and priority signals.
02 Problem extraction
Structure open problems
Flagged passages are analyzed to extract structured problem statements with domain classification, scope assessment, and keywords.
03 Decomposition
Break into sub-questions
Each problem is decomposed into testable sub-questions with evidence requirements, discipline tags, and complexity estimates.
04 Feasibility scoring
Rank by lab-readiness
Sub-questions are scored across six dimensions: biosafety, technique availability, reagent access, cost, protocol readiness, and tractability.
05 Lab packets
Design experiments
Problems classified as "ready to test" receive detailed experiment designs with materials lists, vendor links, protocols, and cost estimates.
Sources: DOE BER workshop reports, eLife peer reviews, NAS committee reports